I have recently been diagnosed with RA and have qualified to be part of a double-blind trial to compare the effectiveness of giving methotrexate alone or alongside abatacept for early treatment into remission of symptoms. I go in on Monday to start the trial and I assume take the first dose of methotrexate (pills) and abatacept (injection) - that's unless the abatacept is a placebo which it might be. I'm not sure if I'll then always have to take the medication on a Monday or whether I can change the day. I am concerned about possible side effects such as nausea that might affect me doing the school run etc. Can anyone advise me of the best times to take pills and what side effects and for how long do they last? Many thanks.