Hi, am new to the site, and am looking for advice! I've been taking mtx 20mg and hydoxychorlide since November with good symptom control. The last 3 to 4 moths I have felt exhausted a lot, despite getting plenty of rest. I could sleep from 6 pm through till alarm at 6 am. I take my mtx on Monday night and my tiredness tends to get worse Wednesday/Thursday. Has anyone else experienced this? I'm reading a lot on fatigue and am worried!