Does anyone else have sero positive RA with a high anti CCP but all the blood markers for inflammation are normal? My ESR and CRP are zero. My Rheumatologist said this sometimes happens. The first month he put me on 10 mg Methotrexate and 5 mg of Prednisone and on month #2 he started me on Humira and tapered off the Prednisone. (I'm happy to be off Prednisone as it made me hyper and crazy) My question is how am I suppose to know if the meds are working? For me I only have the clinical evidence and symptoms. I clearly understand that 7 weeks is too early to know if the meds are working but right now the symptoms jump around. Everyday it's something different. One day it's my ankle, one day my feet then the elbows, etc...I don't know what to expect. What I've read from others is that the symptoms may lessen but don't often just go away ( although that can happens, too) I log my symptoms daily but I find myself not knowing whether it's RA or from something else that's normal. Thank you.