Triple treatment adding Sulfasalazine : Hi, It’s been... - NRAS


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Triple treatment adding Sulfasalazine

ragurl profile image

Hi, It’s been awhile since I have posted. My current meds are Humira, Leflunomide 10 mg, prednisone 6 mg and Celebrex 200 mg 2x a day. I started having more flares. My rheumy wants to add Sulfasalazine. He would like to get the ra more controlled and me off prednisone. I have been using higher does up to 20 mg for the flares. I have been on 6 mg a day for 15 years. Any one have good news or some hopeful experience?

12 Replies

When Hydroxychloroquin and Methotrexate weren't controlling things Sulphasalzine was added and it worked well for me. I hope that it works for you.

ragurl profile image
ragurl in reply to Boxerlady

Thank you. That is good news.

I started on Sulpha when first diagnosed, and mtx added shortly after. It can make your wee bright yellow

ragurl profile image
ragurl in reply to Thingybob

So lots of water to clear the yellow thank you

I tried the Sulfasalazine as I have been on 7.5 of prednisone for so many years. But I couldn’t take it. I don’t usually have problems with meds hurting my stomach but that one did. I was praying that I could use that to get off of the steroids but it just wasn’t good for for me. I hope it works wonderful for you. Fingers crossed! Let us know how it does. HugsPeggy 🙂

Thanks Peggy! That is the thing. Rheumy said only works for 60% and it upsets many peoples stomach. So we will see if I can tolerate it? Fingers crossed.

I had a little nausea for a few days with each dose increase (apart from the last one when I went up to the maximum dose of 3 tablets twice a day) but it passed each time. Interestingly, my long term IBS-C is better than it's been for years but maybe that's coincidence! The bright yellow wee seems to be universal, no matter how much you drink! 😂

ragurl profile image
ragurl in reply to Boxerlady

That is good news especially the improvement of IBS-C. I think it’s original use is for the colon. Yellow wee could be fun 😂 Did it help you get off steroids?

Boxerlady profile image
Boxerlady in reply to ragurl

I was only on steroids for a very short time before diagnosis; since being on DMARDS I've only had a couple of steroid injections.

I'm afraid I couldn't tolerate sulfasalazine at all. Nausea wasn't good but worst thing was the dizziness at times and total loss of taste which took over 3 months to return once I stopped taking it. Sorry! Know its not everyone's experience and some people really get a lot of benefit from sulfasalazine.

ragurl profile image
ragurl in reply to BMCV

I appreciate your experience.

I appreciate your experience.

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