I have very deformed hands, my fingers go to one side, I cannot flatten my hands. I went to see a consultant about a possible knuckle replacement.. He said it was not advisable as I was on too many drugs! I am taking Methotrexate, folic acid,warfarin and BISPRONOL . I think warfarin is the problem although I had a knee replacement last April and I just stopped warfarin for a couple of days before the op. I found this very depressing, in other words, nothing can be done. I don't think I am on that many drugs, most people with RA seem to be on many more.