This is my first post so would appreciate any feedback In the last two weeks my dose of methotrexate has been increased by 2.5mg to 12.5mg per week. I still feel so tired and apart from mouth ulcers I feel pretty crap. I have also reduced my predisilone to 4mg a day and currently my shoulders are burning so much I feel so uncomfortable wearing a bra!!! How long will the increase in meds take to make any difference or should I contact my Rheumy nurse?
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