This is my 3rd week taking Sulfasalazine and was taking 500mg the first week and then 1000 mg and this week had to increase it to 1500mg. I'd been feeling unwell for about a week and my Dr thought I had flu? When I called the Rheumatology Nurse and told her I had itching all over, red rashes all over my legs, felt awful and could not sleep. She told me I'm having an allergic reaction to Sulfasalazine and I must stop taking them straight away. I'm next in clinic on 7th August, she said we would try another drug then. Boy I couldn't believe how bad I felt, itched constantly during the night and could not sleep. I hope I get on better with the new drug. The nurse also said that my neutropenia came back in June, and had dropped 1.2, but the July bloods were much better, so I keeping dipping into neutropenia every now and then. It looks like I'm in for a bumpy ride.