Hello, I am seeing my GP on Monday and she wants me to start on Pregabalin for nerve pain - I take MTX for my RA. I am pleased that she is taking my situation seriously but I have read so much about side effects of this drug. Apparently there can be huge and rapid weight gain and though I know that relief of pain matters more, wouldn't extra weight exacerbate the problems with my knee and ankle joints? I admit that piling on the pounds would make me feel even lower than I do now. Can anyone let me know whether weight gain has been a problem please?