Just as I suspected, after 3 years or so of feeling reasonably comfortable my Enbrel has stopped working to control my sero positive erosive RA. I had a call from Rheumo yesterday to say that there are significant changes in my hands & feet from the last x rays last year, (which I sort of knew there would be anyway, given the pain on the right side of my right foot). They want to trial me on the 6 month intravenous drugs??? I have to go to hospital as a day patient the transfer takes around 4 hours & I think it will be probably be a biological one, have to go on Thursday to discuss with the Rheumatology doctor, so dont know which one yet but am suspecting Rituximab? Is anyone on any of these biologicals? I would love to know if they work & if the side effects are bad, as my theory is that a six month dose, given at once, what if it makes you feel like crap? how do you cope with the side effects & can they reverse them? I have read up on some of this, but would welcome any comments. Thank you all in advance.