I got diagnosed over a year ago. Been on enbrel since May. Was on 22 mg.pills Of mtx.but doc switch me to otrexup ( mtx injections). Took my first injection Tuesday and have been in bed for 2 days with headache and vomiting,and just over all feel like carp. I am going to force myself to work today. Hope I feel better. Hope it is just side effects and nothing more. Any one else feel like this after starting the mtx injections? And does it get better the longer you take it?