I've been on 25 mg of Methotrexate since September 2013. Hydroxychloroquine was then added to the cocktail, but has been stopped because of eye problems. About a month ago, Sulfasalazine was added, 2pd, then 4pd. I know that RA itself causes fatigue, but this constantly drugged feeling is possibly even worse. I am once again on Prednisilone ( tapering v. Slowly from 20mg). Last time the steroids gave me a real boost and I was looking forward to being energised again. But this time, although it has reduced the pain a bit, the fatigue is just as bad. I'm waiting to start Anti TFN and wonder if that will help with the fatigue or make it even worse - if that's possible without going into a coma! Of course, I know everyone is different, but I would really appreciate hearing from others about this big fatigue problem. Thanks in anticipation.
Last edited by Jora
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