Anti ccp negative

[marief]

Just wondering anyone else rf positive but anti ccp negative,? Had a blood result today that's confused me still further !!

[allanah]

Hi Marie, confusing isn't it! The rheumatoid factor can be an indication of RA but it can also be influenced by drug therapy etc. the more indicative test anti ccp is also used but the blood test still don't show the whole I true and I am negative for both! But I have very high esr swelling heat etc so the clinical diagnosis is key! If he sAys you have it, u have it lol. The treatment is the same whatever the blood test results , my Rheumy says they are still not accurate enough at times. Hope u feeling better today x

[marief in reply to allanah]

Hi allanah. Yes ive decided I've got it! Lol! Was diagnosed 20 years ago but my 9.5 anti ccp has confused me. More confusion is over Rituximab as I thought you had to be positive for both to be on it x

[allanah in reply to marief]

I got Ritiximab and am negative for both

[nottsexsportfanatic]

I am strongly postive with my ccp according to my last rheumy letter so I looked it up. I think I have this right. . Strong positive can suggest a more aggressive/errosive type of ra. I believe it also rules out other inflammatory diseaes like lupus. Hope I hsve understood correctly and that this helped unravel some confusion.

[marief in reply to nottsexsportfanatic]

Can you recall your anti ccp level?

[nottsexsportfanatic in reply to marief]

Hi marief,

My ccp is greater than 340, my rf factor is 107.5, ana negative. But remember each lab has slightly different ranges so this might not mean much to others.

[Ronnie63 in reply to marief]

MIne is anti-ccp positive of 1100 which puts me in the aggressive category. My Rheumatid factor is 259. I am ANA negative so no Lupus

[Angela123]

Hi Marie. I am also RF positive but anti CCP negative and didn't know the relevance of this until now. Angela.

[cris1728]

Hi Marie I am RF positive but anti ccp neg also. The medics go on the whole picture and not just the bloods, It is very confusing isn't it when all you want is to know what is wrong with you. I had thought that as I had a positive Rf as well as the joint problems that I had RA but some people without RA can have positive RF. I initially had a diagnosis of undifferentiated inflammatory arthritis and it was nearly a year before I was told probable Psoriatic arthritis ( never had Psoriasis). Am now on Mthx and not doing too bad.

The rheumy's look at the whole picture and the progress of symptoms, signs and investigations so hang in there as there are not always defining lines between the inflammatory arthritis differentials. difficult I know when you want an answer

good luck crisxx

[reef in reply to cris1728]

hi Chris, am suspected to have PsA and am interested to know where you are now with the diagnosis. Is it confirmed in any way RA/PsA?

[marief]

Thanks all. I Was diagnosed with ra 20 years ago. My confusion is the drugs. ..I'm have been on Rituximab since 2008 and although it works, it doesn't work in the way it's supposed to!

My lymphocytes remain high but I have neutropenia with it which apparently is rare so I'm worried about the latest rare side effect that is PML....thinking of a change to either humira or abatcept. ..confused.com!!

[nottsexsportfanatic in reply to marief]

Hi again marie, just seen ur reply re neutropenia. My latest letter from rheumy says I too have neuropenia but I am only on mtx 25mg sub cut. I too saw that it was rare. My rheumy is doing nothing about this so really dont know if I should worry or just trust them. But do feel absolutely rubbish of late.

[marief in reply to nottsexsportfanatic]

Mine went down to 0.3 when I first started Rituximab in 2008. Back up now cos I need re infusion. But considering abatacept now.

[nottsexsportfanatic in reply to marief]

Even with my latest results my consultant is not considering adding extra meds. Said I cant exercise properly. My esr is only 38 so she says im stable enough without charge.

[Victoria-NRAS Partner Moderator NRAS]

Hi Marie

Our article on blood tests might help. It explains that when it is positive, CCP is a good indicator of RA, as it is rarely found in the blood of people who do not have RA, but that around 60% of people with RA are positive for CCP, so you could just be one of the 40% that is negative. Here's a link to the article:

nras.org.uk/about_rheumatoi...

Kind regards

Victoria

(NRAS Helpline)

[marief in reply to Victoria-NRAS]

Thanks Victoria. Yes I read the article but was still confused. Does it mean if you are rf positive but anti ccp negative , you aree still sero positive?

[marief]

Asked my ra nurse and apparently my anti ccp was 10.5 in 2009. ..still not that high

[nettie4lyfe]

Yes, my Anti ccp test is negative but RA is 37.4 so my new rheumy seems uncertain if I have RA. hahave joint, some days I can't work. My Gp says I have it.