I've been injecting MTX for 2 years. A while ago, it was changed to the refrigerated version. I've struggled since then and asked them to change to an easier syringe but got nowhere, so I just struggled. I'm causing massive bruises; they are completely black and purple and the size of my fist, no exaggeration! I mentioned it to my GP who ran some bloods tests but fortunately, everything is normal so we concluded it is my 'stabbing' method. She nagged me to tell my rheumy nurse but I kept forgetting which I know is silly....! Anyway, I'm starting Cimzia on Tues (yay!) and the nurse phoned today to tell me to take the meds out of the fridge before she comes to ensure it's prepared. It got me thinking....I've only ever injected MTX straight from the fridge and I wonder if it should be taken out for a bit to make it easier to inject. Any thoughts?