Chronic gout after transplant

[nlee]

Hello everyone.

I have kidney transplanted 32 years ago. I am suffering from gout attack pretty much right after transplant and until today. My doctor prescribes Allopurinol in a very small dosage because it interacts with Imuran. I like to know if anyone has KRYSTEXXA infusion treatment to reduce gout?

What other medication can replace Imuran? I need to talk to my Nephrologist to switch me to other immunosuppress drug that is not interact with Allopurinol. The uric acid has formed tophi on some of my joints and it is really causing me pain. If the doctor can raise the dosage of Allopurinol, some of the tophi can melt away (that what I was told from the Rheumatologist).

Thanks

[LisaSnow]

I am sure there are other medications that can be considered instead of Imuran. However if you have been taking both meds for 32 years why didn't they consider switching it for you sooner?

[Pegasus2021]

Hi there - I had some side effects with Allopurinol and requested to be on Febuxostat (Uloric) instead. It worked well for me and kept me gout free for years. Though, I do not know if it has any interaction with Imuran.

[Sammi_n_Munk]

Hi there nlee. I haven’t had a transplant but I have chronic gout also (since menopause). I couldn’t take Allopurinol anymore because it was causing too much strain on my kidneys and making me feel very sick every single day (my dose was 300 mg daily), so I was then prescribed one .06 mg of Colchicine daily in order to keep my tophi down to a manageable level. I was told by my rheumatologist that Colchicine is a very powerful anti-inflammatory, but essentially the only type of anti-inflammatory that can conquer the tophi. I would suggest you speak to your doctor about it to find out if it would work with your other transplant meds and still be somewhat safe for your kidneys. I hope it all works out. All the best to you. God bless. 🙏