Kidney cure hype

[Feljon]

What do you think of these si called treatments for ckd on face book and thenet

[Tuffcookie71]

I am interested in one, in particular: Boehringer Ingelheim announced today that it has launched clinical development of its first-in-class IL-11 inhibitor antibody BI 765423 with a Phase 1 study (NCT05658107) to assess the safety, tolerability, and pharmacokinetics in healthy volunteers. Boehringer Ingelheim is already a global leader in the treatment of pulmonary fibrosis, and the initiation of clinical development of the anti-IL-11 treatment reflects the company’s long-term commitment to combat fibrotic disease across therapeutic areas. The IL-11 inhibitor antibody is the first of its kind to reach clinical development stage and is based on a partnership between the Company and Enleofen Bio Pte. Ltd. (Enleofen), with a goal to improve patient outcomes. The FDA has approved a case study of this drug, in the U.S. From what I understand, case studies can last years, but it does sound promising. What a wonderful day that will be when they can find a cure!

[Live4Hope in reply to Tuffcookie71]

I've been monitoring this as well. Reportedly, this was first discovered by a school of medicine, I believe in Singapore, named Duke NUS. Cambridge discovered the marker first but Duke has been researching the relationship between IL-11 for sometime now. In experimental studies they were able to regrow a diseased kidney by inhibiting this inflammatory marker. Duke shipped the research to Boehringer I believe in May so the process has been going for a while now. Exciting to hear the FDA approved the study.

Supposedly, this medication works with the new found evidence that the Kidneys actually regenerate and grow themselves throughout our lives but the issue is this inflammatory marker reportedly keeps the kidney from healing correctly which leads to a cycle of inflammation. Ideally, this medication will inhibit this marker and even with people with little to no fibrosis can benefit from this treatment.

There are even studies now looking at how specific dietary choices can inhibit interleukin-11.

Here's hoping for better outcomes for everyone.

[Pontios in reply to Live4Hope]

Hi Live4Hope, I have been following this as well. Just to clarify the "Today" refers to 9 May 2023. You mention studies on dietary choices to inhibit IL-11. I have seen something on this as well but could not find any specific guidance. Have you by any chance found any specific guidance on a means of inhibiting IL-11 with particular foods or supplements?

[Live4Hope in reply to Pontios]

Only speculations right now. Here are some suggestions I found from cross referencing some Google scholar articles:

Berries 1-2 cups a day

Tumeric 1-2 tea spoons a day

Spinach 2-3 cups a day

Ginger 1-2 tea spoons a day

Kale 2-3 cups a day

Collard greens 2-3 cups a day

Fatty fish 2-3 times a week

Olive Oil 1-2 table spoons a day

Wholegrains 2-3 servings

Legumes 1-2 servings.

The issue is, unlike supplements or medication that specifically targets areas of inflammation with a highly concentrated dose, there isn't a specific portion size or amount that shows clinical evidence of diet interacting with IL-11 specifically but there is significant evidence of reducing overall inflammation for any stage of CKD. There are some Chinese medicine practices that specifically combine the compounds found in ginger, tumeric, greens, danshi, and other herbal roots that is concentrated to where there have been reports of targeting this specific receptor but these test need to be repeated.

I talked to my Nephrologist about what I found and he said he thinks it's reasonable to focus on anti-inflammatory based foods but couldn't speak too much on diet impact IL-11 inhibiting since these studies are too new.

[Pontios in reply to Live4Hope]

Thanks very much for the comprehensive reply

[Live4Hope in reply to Pontios]

My pleasure! I try to only share information that has some clinical documentation behind it or if it lacks clinical documentation then I make sure to express that but the idea that new science is coming out gives people hope and willingness to stick to their health.

[Pontios in reply to Live4Hope]

Well done. I see you are relatively young and stage 2, thus plenty kidney function left. I hope you manage to persuade your GP/PCP or Nephrologist to put you on SLGT2 Inhibitors. I assume you know all the other stuff: No NSAIDs, No PPIs, stay hydrated, limit salt, limit protein exercise, caution on any medication any Dr (bar a Nephrologist) wants to give you (Check it's potential for kidney damage first) etc.

The IL-11 Inhibitors appears to be the best hope of all if they prove successful. I would love to be able to hold out for them.

[Live4Hope in reply to Pontios]

I agree. I'm hoping it'll be available in the next ten years. Even people with ESRD can benefit from what some of the studies are saying.

I've been rolling around with the idea of pushing for an S2 Inhibitor and asked both my doctors (Neph included), both said they don't believe I need it at this time since everywhere else I appear healthy. They aren't convinced I will progress beyond this point right now or at all. Nephrologist said he'll add Farxiga if my GFR hits 70 or lower.

I haven't decided if I'm going to push yet since with my lifestyle changes I've managed to almost remove protein from my urine entirely. My Nephrologist thinks my first elevated number of 61 was a false positive since every other has been in the normal ranges or the machine couldn't detect any abnormalities.

I'd personally prefer the proactive approach and avoid any further decline but not sure what to do.

[Pontios in reply to Live4Hope]

When you now spell that out like that I actually would think your Nephrologist is correct: Introduce SLGT2 Inhibitor only if hits eGFR of 70 or lower.

I note you stated you were overweight. I have a belief (unproven of course) just from some observation that the only people at present who can reverse CKD are those who have been very overweight and then lose weight and make lifestyle changes to keep healthy weight.

You are probably right on the timeline of IL-11 Inhibitors (if successful) being ten years. Unfortunately for me! I could maybe make one, two or three years. Anyway things are good today.

[Live4Hope in reply to Pontios]

That's correct, I used to be overweight, I was 323 at my heaviest. I'm 233 now, I used to be 221 but have been working on building muscle. I started losing weight before the kidney concerns so I try to consider myself lucky that I was already trying to improve my health because I wanted to rather than I had to.

There have been some noticeable trends between significant weight loss and CKD, supposedly it helps with strain and vascular filtration which reduces protein in urine and inflammatory markers which promotes some damage reversal. I think you have some credibility to that point.

Thanks for your input, gives me some peace of mind. I'm hoping for a quick turnaround and wishing positive outcomes for you.

How long have you had CKD if you don't mind me asking? I'm glad to see you're doing okay today.

[Pontios in reply to Live4Hope]

Forty two years now. It started when I was 18 years old. I know I had a clearance of around 60 about 30 years ago. That was when they measured real clearance. You had to bring your 24hours worth of urine with you into hospital, always good fun carrying maybe 2, 3 or 4 litres of the stuff with you on the bus into hospital. About ten years ago I had about eGFR 30, five years ago and up to very recently about eGFR 20 and now about 14 to 15. Feel OK just get tired easily. I still practice martial arts do sparring etc. EPO injections help and especially iron infusions which I get about every year.I found the SLGT2 inhibitor helped a lot. I was already eGFR 20 when put on that.

Thanks for your good wishes. With your analytic approach you will do well.

[Live4Hope in reply to Pontios]

I'm so glad you're still finding ways to live life and I'm happy you're here. Thanks for sharing and I appreciate your kind words.

[lowraind]

so

[WYOAnne NKF Ambassador]

They are all a bunch of "BUNK!" If there was a real treatment for CKD everyone would be taking it! Please understand that once damage is done to your kidneys it is forever. Kidney function can not be returned to normal. Some people can stabilize their function with a kidney friendly diet, but even that doesn't last forever.

My advice, don't waste your money on so-called cures for CKD, because there isn't one!

[Feljon in reply to WYOAnne]

My thoughts so.theyr so convincing to people desperate to find a cure

[Live4Hope in reply to Feljon]

No cure currently but there have been resounding evidence that kidneys have natural healing capabilities but it becomes interrupted by inflammatory markers, specifically interleukin-11.

Standford University Cell studies found, in 2014, the kidneys do repair themselves but the process is interrupted by inflammation. Other schools of study like: University of Texas at Dallas, the University of Virginia, Massachusetts General Hospital, Harvard Medical School, Vanderbilt University Medical Center, and Tulane University School of Medicine were also able to confirm a renewal process in the kidneys. Recent experiments have been focused on targeting these markers.

I personally and holding out hope for what Boehringer discovers during their clinical trials.

Here's hoping for better. ❤️