Local Anaesthetic effect on GFR

[Pontios]

Looking for some advice please? My eGFR has been around 19 to 20 for the last few years. It was 19 in February. Yesterday I got bloods and it had dropped to 14. (Creatnine risen from 297 in February to 370micro mol/L Yesterday).Maybe it just is what it is, i.e. the inevitable decline.

Renal nurse rang this morning to tell me and asked if I had been sick which I hadn't. And asked if any new medications which I could not think of.

Now on considering this in retrospect I had a procedure to remove a growth on my face under local anaesthetic four weeks ago. The surgeon injected five times before he started cutting. (I did flag reduced kidney function to him).

Any experience or knowledge out there among you whether local anaesthetic can damage kidney function?

.

[GoodHealthIsAJourney]

I suggest you contact the doctor's office that performed the procedure and find out specifically what anesthetic they used. Then contact your nephrologist (or do a little research yourself) to get answers. Articaine is the safest local anesthetic for patients with liver and kidney disease.

[Pontios in reply to GoodHealthIsAJourney]

Thank you for your reply. I have done that it was "Lignocaine with adrenaline". I have also forwarded this to my Nephrologist. Just from the research I have done and the fact that people have not replied with experiences of negative impact on eGFR I do not now suspect the Local Anaesthetic. My Nephrologist had increased my diuretic dose from 40mg Furosemide once daily to twice daily (As well as adding a phosphate binder and doubling Vitamin D dosage). I am now suspecting the increase in diuretic dose is the cause of my drop in eGFR

[Whitetail66 in reply to GoodHealthIsAJourney]

My nephrologist said that local anesthetics are not a problem. I have had a lot of dental work done in the past couple of years- 5 crowns, two root canals and a crown lengthening procedure (which was three hours of torture 😆). My GFR has remained stable through all of it. I’ve also had two major surgeries in that time frame (torn distal bicep tendon and a tibial plateau fracture, which is the worst fracture one can get. Yea me!🤣). It sounds like you may have figured the issue out with the increase in your medicine. Best of luck!

[Pontios in reply to Whitetail66]

Whitetail66, thank you for that. Thatis good insight to get. You must be doing some extreme sports to get that arm tendon tear and bad leg break.

[drmind]

I do think that the anesthesia does effect our GFR. A few years ago, I had a dental root canal and had tons of anesthesia [not sure what] and my GFR fell several points and never returned. I had other issues with dental pain at the time so I did not explore the anesthesia issues then. Now, just two weeks ago, I had oral surgery again and have no idea what anesthesia was used. Also, I had problems with the antibiotics used [amoxicillin] and was sick for a week or so. I should have been prepared when the dentist asked me about what is best to used, but foolishly I wasn't. I am scheduled for labs in a few weeks and will see then if more GFR damage was done. I now have the names of best antibiotics to use with rental impairment in my purse and intend to ask my neurologist whats the best anesthesia to use so I can be ready.

[Pontios in reply to drmind]

Thanks for that drmind. Sorry about your unrecovered loss of GFR. Indeed I believe antibiotics are also a culprit as well. I noticed recently that my GP had recorded that I am not to have a particular antibiotic.

[Merny5]

Good question Pontios. I don’t have the answer but I wish I did. Perhaps someone will respond to your inquiry