New drug for CKD?

[horsie63]

Dr. Sanjay Gupta harking the benefits of Klotho protein on Facebook in helping with CKD.

klotho.com/#:~:text=Klotho%....

The US Food and Drug Administration (FDA) has recently approved a breakthrough new drug for the treatment of adult kidney disease, marking a significant milestone in the prevention and treatment of chronic kidney disease (CKD). This new therapy is about to completely change the treatment pattern of chronic kidney disease. I have already broadcasted this news on CNN News last week, but I still want to write this article on Facebook to tell more people who haven't seen the

Has anyone heard of Klotho? Or is this a scam?

REVITAHEPA™Renal Awakening Drop【Healthy 🥬, Pain-free 🌟, Non-recurrent 🏆】🥬 The bottle is 30 ml and cost $40

[S_dillow]

it sounds like manipulation....ii havent found any other reference to klotho but id be cautious either way.if this was such a breakthrough drug big pharma would be selling it for more than 40 a bottle.

[horsie63 in reply to S_dillow]

Personally I don't trust any "drug" sold on TV or the internet. I doubt there's anything that can repair the damage done to my nephrons.

[S_dillow in reply to horsie63]

agree with you there.so many snake oil salesmen these days

[drubina111 in reply to S_dillow]

I ordered this Klotho drops for my husband as he has stage 4 CKD. Unfortunately, it doesn't work. There were no positive results. My request to all, please do not spend your money on these fake tall claims.

[S_dillow in reply to drubina111]

sorry about that.hlf the reported cures out there are no more than vitamin or thc supplements sold at extravagant prices to desperate people.its truly a shame.

[Bassetmommer NKF Ambassador]

You mention REVITAHEPA™ which pops up a drug for men, but every time I go to see what it is it is a scam....... not sure if that was what you meant.

[jodaer]

I mostly trust Dr Gupta and the FDA has approved it? I wouldn't take it but would keep it on my list to keep up with.

[WinJ3]

It’s likely a scam, but The US Food and Drug Administration (FDA) has approved Vafseo (vadadustat) Tablets for the treatment of anaemia due to chronic kidney disease (CKD) in adults

[nonna70]

I found some articles about Klotho on NIH but don't have much of a clue what they said! smile

[orangecity41 NKF Ambassador]

Here is a link to information from National Kidney Foundation on Klotho dated April 2024 stating outcomes unresolved. ajkd.org/article/S0272-6386...

[jodaer]

True but famous doctors do endorse products sometimes. Not talking Dr Oz famous. As I said I wouldn't take it based on what I read but would keep an eye and see what happens.

[CrazyFloridian]

Klotho and the ad for REVITAHEPA are not related. Go to the Klotho website. Looks and sounds legit to me.

[Darlenia]

Thanks for bringing this up, Horsie! This is a very intriguing and promising field of study. Your post led me to research it and I discovered Klotho is an anti-aging membrane protein predominately produced in the kidneys. This came as a complete surprise to me - not only are kidneys responsible for filtering and producing hormones, but also Klotho! Who knew? Anyway, Klotho is essential for life - a lack of it has a profound influence on diabetes, cardiovascular health, brain health, and even kidney health. It's heavily linked to organ and muscle protection and a lack of it can lead to organ injury, early death, etc. The problem is that the field is very new and there are many Klotho phenotypes. Hence, therapies developed so far have been inconclusive. But, with additional funding and new approaches into formulas and therapies, the field holds significant promise. While proteins get a thumbs down here and there, they're very important - in the case of Klotho for protecting organs and muscles from deterioration. (I'm still wrapping my head around the fact that it's largely produced inside one's very own kidneys....) Anyway, this is great research report from the field of gerontology explaining the situation. ncbi.nlm.nih.gov/pmc/articl...

[horsie63 in reply to Darlenia]

I go for my meeting with the transplant nephrologist on the 21st and plan to bring this up. I know from the biopsy my kidneys are damaged so I don't think even this would help BUT when I get the transplant perhaps I can keep her happy for a long time.

The key point is how to either activate it in the body or is the drug Dr. Gupta advocates a way to get it. Guess I'll wait and watch.

[Darlenia in reply to horsie63]

Exactly. And I believe you also have a genetic issue - maybe help with that too. Sheesh - I just love seeing promising things out there. I hope funding for the sciences strengthens as the years go by fast. It's the only way a lot of diseases will be fixed.

[bbeba103]

Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease—a comprehensive review from the ERA CKD-MBD working group

Klotho, a multifunctional protein, acts as a co-receptor in fibroblast growth factor 23 and exerts its impact through various molecular pathways, including Wnt, hypoxia-inducible factor and insulin-like growth factor 1 pathways. The physiological significance of Klotho is the regulation of vitamin D and phosphate metabolism as well as serving as a vital component in aging and neurodegeneration. The role of Klotho in aging and neurodegeneration in particular has gained considerable attention. In this narrative review we highlight several key insights into the molecular basis and physiological function of Klotho and synthesize current research on the role of Klotho in neurodegeneration and aging. Klotho deficiency was associated with cognitive impairment, reduced growth, diminished longevity and the development of age-related diseases in vivo. Serum Klotho levels showed a decline in individuals with advanced age and those affected by chronic kidney disease, establishing its potential diagnostic significance. Additionally, multiple medications have been demonstrated to influence Klotho levels. Therefore, this comprehensive review suggests that Klotho could open the door to novel interventions aimed at addressing the challenges of aging and neurodegenerative disorders.

More in the link :

academic.oup.com/ckj/articl...

[bbeba103]

Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake

nature.com/articles/s41598-...

[horsie63]

Well...if you have medium to high levels of potassium in your lab work you are told not to eat potassium rich foods like bananas and melons, etc.

[Marvin8 in reply to horsie63]

Unless your potassium levels are above 5.0, most nephrologists have no idea what to say, but they feel the need to fill the air with vibrations, so they make sound.

[Darlenia in reply to Marvin8]

Your graphic phrase, "they need to fill the air with vibrations, so they make sound" made me chuckle.

[horsie63 in reply to Marvin8]

And people wonder why I call the ones at the dialysis center "drive by doctors". They come by with their laptop on a rolling cart and one of the nurses tags along. They stop at each chair and ask "how is dialysis going". Visits typically last 5 min or less. This month I only "saw" my nephrologist via a tablet...he didn't even come in an make vibrations.

[Marvin8 in reply to horsie63]

And not to forget, they all own a piece of their dialysis centers. I believe it's called a conflict of interests.

[S_dillow]

interesting info.i really hope this pans out

[FelineFandom146]

Interesting info you posted. Thanks for sharing! I haven't heard of Klotho and I do try to keep up with anything related to CKD/PKD. your post piqued my curiosity and I had to look it up. Lots of info about it, It seems it has great potential but it still has a while to go before they actually promote it. We'll all definitely want to keep and eye on it. It'll be interesting to see how this progresses. Let's hope it is soon. I'd be interested to know if it indeed has been approved by the FDA for I haven't been able to find anything about that yet. I looked under both names and nothing found under FDA approved drugs.