experience with antibiotics damaging kidneys?

[mendobear53]

I am 70yrs old woman gotten diagnosed last year with Stage 3 CKD. i had an infected tooth a few months ago and was given Amoxicillin 500mg 3 times a day for 10 days which cured the infection,

a few weeks after that I had a plummet in eGFR from 40's to upper 20's and had to go to ER to get rehydrated via IV because of severe vomiting for several days. Now I have another infected tooth and dentist wants me to start Amoxicillin again. Can not reach Nephrologist for 3 days. any thoughts or experiences to share?

MendoBear

[Pontios]

Here is a link to a PDF from the Irish HSE on dose adjustment in CKD. At stage 4 it say max 500mg Amoxicillin in 24 hours.hse.ie/eng/services/list/2/...

[missdc]

I always ask for a drug that is excreted through my liver, if possible. A lot of medications have a possibility of causing an acute kidney (or liver!) injury but it's usually rare. Less rare if you already have kidney damage though

[Darlenia]

Members are giving you good information re amoxicillin! Kidneys work hard to filter out those dental infection toxins from bloodstream - and that too can lead to eGFR decline. I'm really glad you and your dentist are on the way to taking care of it.

[barbara55109]

The dentist should adjust your dose. There are formulas and calculations to be done. When I needed penicillin the minute clinic nurse and cvs pharmacist at the minute clinic consulted with each other to determine the best antibiotic and did calculations based on my current eGFR and weight. I was so grateful for the care and attention to detail. If the dentist doesn't know what to do insist the consult with a skilled pharmacist.

[pheebee]

I think with antibiotics (and possibly with an infection also) they temporally reduce GFR, but it does seem to bounce back once treatment is completed. My elderly dad had several courses of IV antibiotics lasting several days over a few weeks and his GFR went down to 17 during treatment. Once the infection was resolved and treatment was completed it went back up to 47 over a few weeks or months.

I've also had antibiotics for teeth and it doesn't seem to effect my GFR long term.

I think severe vomiting would probably also effect GFR.