Spironolactone for reduction of protein

[Scoutie]

Type 1 Diabetes for 58 years. Current EGFR of 24, serum creatinine 2.16. Recent blood tests showed proteinuria of 1711. Saw nephrologist this past Monday and he put me on Spironolactone 25 mg in order to reduce elevated protein. He also put me on Sodium Polystyrene Sulfonate (SPS) Powder which reduces potassium (Spironolactone increases potassium). I'm concerned about taking the SPS since it can have so many side effects. Has anyone else ever used it and if so, any issues?

[Bassetmommer NKF Ambassador]

My husband was on it. they took him off because of the potassium. He too has CKD, Stge 3a

[jodaer]

I have stage 4 ckd. My neph put me on spironolactone and it did reduce the protein but also increased the potassium. She took me off the spironolactone. potassium went down. One of the reasons she stopped it my pharmacy couldn't get it.

[Scoutie in reply to jodaer]

To counteract the expected increase in potassium, I have also been given a prescription for Sodium Polystyrene Sulfonate (SPS) which will counteract the increase in potassium so hopefully a net net. It's the potential side effects of SPS that have me concerned.

[Bobbybean]

Hi I m on spironolactone -100mg. And I also take lokelma powders to counter the potassium. At first I took 10 mg per day but then down to 5 mg. It takes a few months to settle down but it really does deal well with the proteinuria. The lokelma powders are expensive£300 per box of 30 Another reason to stop you from accessing this medicine

There is a medicine sparsentan but its not licensed in the uk yet

Sometimes in the uk it seems like DIY renal medicine coupled with a postcode lottery

.

[Scoutie in reply to Bobbybean]

Thanks for your response. It looks like lokelma and SPS are the same class of drugs. Have you had any side effects?

[Bobbybean]

Hi. Only upset tummy but nothing that you cant cope with. The drugs acts as a diuretic aswel so less leg swelling but more trips to the loo!!