Newly Released Real World Mavenclad Study

[Raingrrl]

My neuro is contemplating switching me from Ocrevus to Mavenclad once my immune system is in better shape. This study gives me pause because it states: “Moreover, we identified better outcomes in patients exposed to a lower number of previous DMTs, suggesting that cladribine might be more effective when placed as an early treatment along the treatment algorithm.” I’ll be talking to my neuro about this. But first I have to get my immunoglobulins back into the normal range!

link.springer.com/article/1...

[erash]

I just read the abstract but wonder if the lower NEDA in people who’d been on more previous DMTs was a confounding variable that suggests those people had been on more DMTs because they had worse and longer standing disease, not that previous DMTs interfered with Mavenclad. Maybe that’s what u meant?

[Sandydemop in reply to erash]

good theory erash

[Raingrrl in reply to erash]

Interesting perspective erash . I’ll bring that up to my neuro too. Thanks!

[kdali]

I think the purpose of the study was to prove it should be allowed as a first or second treatment, because it's use is often limited by a requirement of second line drug failure.

[Raingrrl in reply to kdali]

Maybe so. I’m keep trying to find data to help me make the decision when the time comes. I like erash ’s perspective too. Hadn’t thought of that.

[twooldcrows]

i would ask the doctor more questions about it ...good luck it is scary not knowing what ya should do or not do.....take care and talk it out with the doctor till you are convinced that this is a good idea....love and happiness...