Allergies

[Karen-x]

My friends, do allergies have the same impact on MS SYMPTOMS as viruses, fevers, infections? Seems that it would as allergies activate the immune system? Or is it different somehow?

[kdali]

Karen-x Yes allergies activate Immune globulin E, I believe, this is also how Copaxone works in the first 4 months of treatment. But to say it directly impacts MS symptoms? Its question enough to have caused studies the give participants antihistamines!

[Sukie427 in reply to kdali]

Wow! I never knew this. I've had allergies to dust and certain pollens all my life, and I have never felt an effect on my MS when my allergies are acting up. Either I got lucky or I just don't notice any effects.

[Morllyn]

I have often wondered the same thing.

[jimeka]

I hope not as I cannot take antihistamines as they set off my RLS, 🦋 🌈

[kdali]

Allergies have not increased any MS symptoms for me. I think it's one of things that will be person to person, like fatigue and sunlight or sleep and magnesium. I'm trying to find the study and what they used, it's over the counter.

[kdali]

I was wrong, it was not used to reduce MS symptoms. The drug is Clemastine or Tavist and was used for remylenation. There are several articles about it and the study was very small.

[Karen-x in reply to kdali]

Did the study show any remylination? I guess it was in mice?

[kdali in reply to Karen-x]

Karen-x Yes, in people, but it was a small study and only for ON patients, they tested the nerve delay. i can't find the real study, just news reports. ON can repair itself within 6mo of onset of symptoms, I can't tell if these people were like me with permanent damage or if they would have recovered anyway. There were mice at some point in the study. I think the results were released in phase two. I can't take Tavist right now, so I have not searched for long today, but it's published somewhere with a dose and graph of the cohort, surely...I hope. I did read an increase of fatigue symptoms due to the antihistamine effect. I'd take it for sure if there is a chance it helps, that drug is old as dirt. Id love to see some MRIs also!

[erash in reply to kdali]

kdali hmmm...tavist IS an antihistamine. I wonder what the mechanism is that remyelinates?

Does copaxone activate IgE because of an allergic reaction to its proteins (worse in some than in others) not because of its mechanism of action?

[kdali in reply to erash]

erash I believe that's the assumption via "tolerance". After the 4 months, something else takes over and that knowledge ran out my ear a while ago 😂 Even though half of what you read ends up with "we don't really know how it works", I find what they do know really interesting, scary, or frustrating. The new generations they tried to make have killed the animals in a short time. Just a lil tweak and dead. Craziness! They also have a promising nasal spray, but they are using it on Alzheimer's patients at Cedars Sinai right now, it's in phase two. I fell in the floor when I read that because I'd much rather snort that shoot!

Sorry, I nerded out a bit there 😂

[erash in reply to kdali]

kdali

😂😂😂

I think I found someone nerdier than me 🤓

Cool👍

[kdali]

Tavist made the review!

mymsaa.org/publications/msr...