Hi. I have PMF, and rux was making me anemic and tired. Running a personal cold chain so that I could use EPO injections to boost Hb was beyond me. Using Rux on its own ( 15 mg twice a day) needed transfusions to maintain Hb. Short trial of pegasys made me v depressed. I’m clearly susceptible to depression as a side effect.
Might be worth trying reducing the dose of momelotinib ( at present 200mg on alternate days) : its keeping my Hb at normal levels , and giving me more energy, but if the price is depression its not worth it.
Wondered if anyone else has had similar issues.