Pharmacological stress test for dizziness and br... - MPN Voice

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Pharmacological stress test for dizziness and breathlessness?

PupsBestFriends profile image
8 Replies

Due to ongoing symptoms of shortness of breath and dizziness, my GP has ordered a pharmacological nuclear stress test. Anybody else have this test or thoughts about it?

Short background- Diagnosed with PV in late 2021; symptoms began shortly after, even when on 81mg aspirin only. Now on Besremi for two years and have CHR for over a year. Previously have addressed iron issues, had neurological evaluation and testing, cardiac evaluation and two-week heart monitor, brain MRI, and much more. These evaluations all returned with excellent results.

At visit with GP he displayed my latest blood results. He said the blood levels are normal, so PV cannot be causing these symptoms. I'm nervous about the test because it elevates heart rate, and side effects can be dizziness, shortness of breath, or chest pain. These effects can be "a side effect or a major complication". Yikes.

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8 Replies
hunter5582 profile image
hunter5582

The "Yikes" response is certainly understandable. It is important to get to the bottom of the symptoms of dyspnea and dizziness. There are a couple of factors to be taken into account. One is that these symptoms can occur with PV even when the blood cell numbers are well controlled. The other is that Besremi can have both of these symptoms as side effects. These symptoms can occur for other reasons as well.

It is unlikely that the GP has the treatment of PV in scope of practice. This is really a question for a MPN Specialist to address. It may ne that the pharmacological stress test makes sense, but suggest that you seek an expert opinion of this issue.

Please let us know what you learn and how you get on.

PupsBestFriends profile image
PupsBestFriends in reply tohunter5582

Thanks hunter, your thoughts echo mine. Can't wait to hear what my MPN hemo says.

PhysAssist profile image
PhysAssist

Hi PBF's,

Hunter is, as always absolutely correct.

Here is more information about the actual test., which is generally pretty safe and provides a pretty good evaluation [bested only by cardiac catheterization] of blood flow and estimation of areas of ischemia [reduced blood and oxygen flow] in the heart muscle. It is mainly used in patient who for whatever reason couldn't perform a bike or treadmill stress test.

What is a chemical stress test:

"A Lexiscan [a brand name for the chemical used] stress test is a nuclear imaging procedure that uses a medication to increase blood flow to the heart:

Purpose

Determines how well blood flows to the heart and if there is coronary artery disease

A Lexiscan stress test is a nuclear imaging procedure that uses a medication to increase blood flow to the heart:

How it works

A nurse injects Lexiscan into an IV while the patient is monitored. The medication makes the heart respond as if the patient is exercising.

What it shows

The test takes pictures of the heart before and after the injection to show how well blood flows to the heart muscle.

Who it's for

Patients who are unable to exercise or can't exercise for very long

Risks

The test is generally safe, but risks include heart attack, abnormal heart rhythm, fainting, and shortness of breath. Risks are higher for patients with blocked arteries.

Here are some things to know about preparing for a Lexiscan stress test:

Avoid caffeine for at least 8 hours before the test.

Stop taking certain medications at least 24 hours before the test, including TheoDur, Theo24, Theophylline, Aggrenox, Persantine, Slobid Aminophylline, Slobid, Uniphyl, Trental, or Pentoxifylline.

Wear comfortable, loose-fitting clothes and shoes.

Discuss any history of bronchodilator therapy, seizures, or allergic reactions.

Lactating women should pump and discard breast milk for 10 hours after the test.

Also: bvhealthsystem.org/media/fi...

Best wishes, and I hope this helps...

PA

PupsBestFriends profile image
PupsBestFriends in reply toPhysAssist

Thanks PhysAssist, this is a good breakdown for the procedure. The info I've reviewed also says this test is typically safe, but of course this refers to the general population tested, and not specifically PV patients. I'm just unsure if this is procedure is necessary based on previous cardiac evaluations, testing, and imaging I've already had.

When I explained to the GP that top MPN Specialists have documented these symptoms can exist even after CHR due to vasoconstriction and inflammation, he stated they were "grasping at straws". My confidence in his opinion is less after his statement.

pmc.ncbi.nlm.nih.gov/articl...

"Other major complications include death, cardiac rupture, cerebrovascular accident (CVA), and cardiac asystole (<0.01%). A multicenter, international registry study of 71 centers by Varga et al. found that the risk of life-threatening adverse events in 35,103 total patients undergoing dobutamine stress echocardiography was roughly 1 in every 557 patients (0.18%, 63 total)"

PhysAssist profile image
PhysAssist in reply toPupsBestFriends

Hi PBF,

You're totally welcome, and if your cardiologist says you need it, that's one thing, but if Cards thinks you're good already, and it's just the GP driving further testing, I'd be refusing it.

Also, as you say, his or her statements undermining and denigrating MPN specialists' understanding of the disease they are specialists in treating is in itself worrisome.

FWIW, I can echo Planti's experiences, although I had the actual exercise [treadmill] stress test for SOB w/ exertion and early fatigue [not the chemically-induced one], and this was about 5 years before my eventual diagnosis w/ JAK@+ PV and Tx w/ Besremi.

While the exercise was very difficult and taxing, [exhausting] the test results supported the previous tests concurrence that my cardiovascular health was excellent overall.

BTW, my symptoms of sob on exertion and early fatigue [not to mention limb heaviness and generalized pain ] have been mitigated significantly [not to say resolved 100%] since I have been on the INF at what for me seems to be the effective dosage.

Best wishes,

PA

Planti profile image
Planti

Hi Pups, I have Jak2 ET and have been ordered a pharmacological stress test to sort out an abnormal EKG (routine preop no history of heart problems). It is pharmacological because I have breathlessness and need a hip replacement so I can't have the usual exercise stress test.

Something to be reassured about is that you have had good results on cardiac evaluation so it is unlikely that speeding up your heart with drugs will cause major problems. Also they can reverse the drug effect right there. This is a common test for those of us with exercise constraints. I had an appointment with my MPN specialist and we discussed the breathlessness, she had no problem with my having the pharmacological stress test and is keen to get results as I am on interferon (Pegasys).

Never a bad idea to relate symptoms to MPN specialist as they may be caused by either your PV or meds. With the silo effect in place in medicine, it is often up to us to make sure everyone entrusted with our care knows all the goings on.

Hope you get your answers.

PupsBestFriends profile image
PupsBestFriends in reply toPlanti

Thank you Planti. Some of my hesitation comes from a history of terrible reactions to medications. I just find it odd that my cardiologist says my heart is in excellent health and can clearly explain the mechanisms of PV that cause these symptoms, yet my GP denies this possibility.

Best wishes to you, and please let us know how your test goes.

RoundTheWorld profile image
RoundTheWorld in reply toPupsBestFriends

Hi PupsBestFriends. How did your cardiologist explain the mechanisms of PV that caused dizziness and breathlessness please?

Thanks - and hope your MPN Haemo advises you on best way forward soon.

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