I noted in that post a thought of using a non pegylated IFN as a temporary measure as Pegasys becomes unavailable. It may not be so out-of-the-box thinking. This reference shows its use, and provides a dose schedule and relative dosing vs PEG. If you are out of viable options, (cannot access Bes or Rux, or a clinical trial, intolerant or refractory to Ana and/or Hydrea) this could be worth a Dr discussion to use this less convenient option till PEG becomes available again.
For example one could start with the lowest dose here (3MIU, 3Xper week) and increase as needed. Your Dr would need to be trustworthy, knowledgeable and agreeable to go for it but it could be worth an ask if you're out of options.
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mpnallianceaustralia.org.au...
"Roferon is a short-acting interferon alpha available ...for patients with a MPN associated with a high platelet count. It is usually given 3-5 times per week. It is available as a single dose syringe containing the exact amount of drug (3,6 or 9 MIU) required for one injection"
"Pegasys is a longer-acting formulation (pegylated-interferon) which is injected only once a week and sometimes less often. ... It is available in either 135 ug or 180 ug prefilled syringes. It is usually commenced at a dose of 45 ug weekly and the dose is gradually increased depending upon tolerability and efficacy""
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