Anyone else had platelets reduce?

[Itchy-Scratchy]

Hi, my platelets have been reducing during the last 12 months and wondered if anyone else has experienced anything similar? I had a slight reduction a couple years ago after my Covid vaccine and booster but not had a vaccine in the last year.

I am only on aspirin and simvastatin, 64, pretty fit, slim, active and vegan. I have not changed anything over the last 12 months except maybe a slight increase in exercise.

Has anyone else had platelets go down?

Thanks

[hunter5582]

It is normal for platelets to cycle up and down. Platelets can change by as much as 100K in a single day based on what is going on in the body. My platelets used to cycle from the 500s to the 700s. They could go the the high 900s when I was experiencing additional reactive thrombocytosis. Suggest reviewing your degree of cycling with a MPN Specialist for the best case-specific explanation.

[Itchy-Scratchy in reply to hunter5582]

Thanks, will ask my MPN specialists aboiut that.

[ritaandscooter1]

I'm about the same age as you and have had PV Jak2 for over 20 years in which I've been on 2x aspirin a day. Like you I'm also fit, active and fairly slim. Back when I was diagnosed around age 43 my platelets reached 1700 and ever since have been trending downward to 700. I forgot to ask my hematologist on my last visit why this is so. Interesting! Don't have a explanation. Kerry

[Batman66]

Similar to you (age68), I'm on 75mg aspirin & simvistatin. Active, healthy diet. My platelets have been under 500 for over a year . No venesection required in 9 months.

[George1976 in reply to Batman66]

Simvistatin has anti cancer properties even though it was intended for cholesterol. I suspect that it is helping your MPN. pubmed.ncbi.nlm.nih.gov/343...

[Itchy-Scratchy in reply to George1976]

Thanks for the info and the link George.

[Itchy-Scratchy in reply to Batman66]

Great news. Thanks

[Itchy-Scratchy]

Thanks you all for your kind informative replies.