Renal stenosis

[Kelly2]

Hi. I started Hydreasin two years ago one capsule a day. Last year it was found I had obstruction of ureteroreanal junction. out of the blue. I suffered much pain and in two days I am having surgery. I read somewhere that Hydroxy does that. Any idea about it? I am thinking of changing to Besremi as I have enlarged spleen and liver and I also have saturation. I need to see the haematologist.

[hunter5582]

Hydroxyurea can cause renal impairment but I have not heard of it causing renal stenosis, which is a narrowing of the renal arteries. Renal stenosis in the context of PV would be a significant risk and definitely needs to be addressed.

Discussing a change to Besremi or Jakafi in the situation you describe would be a very reasonable thing to consider. Hopefully, you are already consulting with a MPN Specialist who is experienced with all of the treatment options.

[Kelly2 in reply to hunter5582]

It is called obstruction of ureteroreanal junction.

[hunter5582 in reply to Kelly2]

That is different than the arterial renal stenosis. Hopefully the plan is for a laparoscopic surgery. I do not think this issue is related to the hydroxyurea.

Wishing you an uneventful surgery.

[Kelly2 in reply to hunter5582]

Yes laparoscopic robotic. If stones caused it could it be hydroxyurea? Did you have side effects with Besremi? Is this interferon? Thank you.

[hunter5582 in reply to Kelly2]

I do not think this kind of stenosis is cause by stones, but suggest you ask the urologist that question.

Besremi is a form of interferon, ropeginterferon alpha 2b. I have found it to be more effective and easier to tolerate than the other treatment options I have used. The side effects have been itching.occasional rashes that are well controlled with Zyrtec, elevation in LFTs that is well controlled with milk thistle extract, and mild lymphopenia/borderline neutropenia. The decrease in leukocytes is a dose-limiting factor for me. I am maxed out at 175mcg, which is a low dose. Fortunately, this doe works for me. I am pleased that my JAK2 allele burden has dropped from 38% to 10%. I feel better now than I did before starting on the interferons. In fact, I feel better now than I did 10 years ago.

Hope the surgery goes well.

[Kelly2 in reply to hunter5582]

Thank you. I hope the fact that I have hypothyroidism will not prevent me getting it.