A bit of advice please.

[YBSx]

Hello Everyone

I have ET JAK2 and currently taking Hydroxycarbamide. I have be reading about ruxolitinib and wondered if anyone out there takes this medication to treat ET JAK2 ? I have read that this is to treat PV whilst also read about it being used for ET JAK2 so I’m a bit confused 🫤

Yvonne

[hunter5582]

Ruxolitinib has been in clinical trials for ET, but does not have a label indication for ET. It has been used off-label for ET. Due to the considerable expense, accessing ruxolitinib for off-label use can be a challenge. Note that technically, hydroxycarbamide use for ET is also off-label, though it is in common use. However, hydroxycarbamide if very inexpensive. To compare the retail costs in the USA, HU = $25/60 caps. RUX = $14,308/60 caps.

So to answer your question, ruxolitinib is used off-label for ET, but it is not common due to the expense. The two recognized first-line treatment option for ET are hydroxycarbamide and Pegasys (which is also more expensive ($4,300/month). Both of these options are off-label for ET, but are in common use.

Hope that answers your question.

[william-Indo in reply to hunter5582]

Drugs prices in US so expensive.Rux in Malaysia just RM.21000 per box (USD.4.450).

If you join the program, buy 1 box will get 1 box for free.

Pegasys 135mcg is RM.1.870 per vial (USD.450).

Hope others have insurance cover as you are.

Cheers

[YBSx in reply to hunter5582]

thank you for the information it’s very helpful