High Ferritin, LDH & ALT

[Threelions]

Hi Friends,

I’m ETJ2+

My last bloods showed

Ferritin- 490 (says max normal is 200)

LDH- 268 (says max normal is 220)

ALT- 99 (says max normal is 55)

I was just after increasing my knowledge of the above blood readings and their relationship with ET/MPN

I’ll speak to Guys in due course at my next appt. but rather than googling I wondered if anyone could explain further what importance Ferritin, LDH & ALT readings’ are what they indicate in blood tests.

Many thanks in advance.

Mark x

[hunter5582]

Elevated LDH is not uncommon with MPNs. The short answer is that when you have hypercellular activity in the marrow, you get more cellular turnover and you get elevated LDH. There is more to this issue that you can discuss with your MPN care team.

ALT is one of the liver function tests that are routinely done. There can be a number of reasons why ALT, AST or other LFTs are elevated. It is fairly common when taking interferons and other medications.

The elevated ferritin does need follow up. There can be a number of reasons for this elevated iron storage number. It needs to be interpreted in the context of the other numbers in a full iron panel.

• Serum iron. This test measures the amount of iron in your blood.

• Serum ferritin. This test measures how much iron is stored in your body. When your iron level is low, your body will pull iron out of “storage” to use.

• Total iron-binding capacity (TIBC). This test tells how much transferrin (a protein) is free to carry iron through your blood. If your TIBC level is high, it means more transferrin is free because you have low iron.

• Unsaturated iron-binding capacity (UIBC). This test measures how much transferrin isn’t attached to iron.

• Transferrin saturation. This test measures the percentage of transferrin that is attached to iron.

webmd.com/a-to-z-guides/iro...

Reference Ranges. Note that may vary by lab.

Ferritin 15.0 - 200.0 ng/mL

Iron 50.0 - 212.0 mcg/dL

Iron Binding Capacity 250.0 - 425.0 ug/dL

Iron, % saturation 20.0 - 50.0 %

Iron Binding Capacity 250.0 - 425.0 mcg/dL

Iron Binding Capacity (unsaturated) 155.0 - 355.0

This is an issue to review with your MPN care team. Please do letus know what you learn and how you get on.

[Threelions in reply to hunter5582]

Thanks, as always, for your reply Hunter. Your contributions here are fantastic & it’s always good to add to our knowledge.

Since posting my caeruloplasmin result came into my file.That showed as low.

I’ll e mail Guys & get their thoughts on it.

I’ll also be sure to let you know what they say.

Thanks ever so much again for sharing your knowledge.👍

Mark

[ainslie]

the LDH is quite good for MPN, ALT may be transitory , can be due to many unimportant things but best monitor and report if stays up, ferritin needs investigating, maybe ask Guys sooner than later

[Alexbits]

I have had high ferritin when my interferon (Pegasys) dose was higher. See healthunlocked.com/mpnvoice...