Covid Shot, benefit of side effects

[EPguy]

I got my 4th shot two days ago. I had been waiting for the bivalent (Omicron Ba.5 + Wuhan-Hu-1) since only Omicron is out there now. I also waited for the Moderna version since it is a higher dose, as discussed in various posts before.

This recent report found side effects are useful, although they did not present the data easily. Importantly there was still a response absent side effects so most likely no worries if it didn't happen. This seems to have tested only the original vaxes, not bivalents

I was hoping to feel ill afterwards to know my WBCs are watching. I got my wish, fever at 100F, light flu like, etc for the next day. Different from the usual MPN malaise. Better that than getting infected (we had Covid early 2020, a super bad near death experience.) Also lots of injection site pain, same as the Shingles shot.

My 1st three Pfizer shots had very few effects.

For dose- Moderna is 50mcg, Pfizer is 30mcg each split 50/50 for each Covid variant so Moderna has 25 of Wuhan-Hu-1 and 25 of Ba.5, Pfizer has 15 of each:

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From this report ( I meet the last two criteria, are other members matching some of these criteria?) Younger and Moderna make sense, but the other correlations are not clear.

"symptoms were associated with younger age, female sex, prior infection, and the mRNA-1273 (Original Moderna) vaccine... systemic (thru the whole body vs injection site pain) symptoms remained associated with greater antibody response in multivariable-adjusted models"

No side effects does not mean no response, "In this generalizable cohort, nearly all participants exhibited a positive antibody response to complete mRNA vaccine series." But they found less.

jamanetwork.com/journals/ja...

In this figure (not well laid out) the lower bar of each pair is the better response so for example "local symptoms only" in the 2nd text line has way less response than "Systemic..." in the 3rd line.

But I can't figure it out as there are too many variables.

[Paul123456]

Did you have your vaccine close to a Ropeg injection? Wondering if dosing up with interferons at same time as vaccine might turbo boost side effects? Meant to exercise the arm as well for better response.

[EPguy in reply to Paul123456]

I did my Bes just the day before. Could be some connection to that.

I forgot to massage the Covid injection area, that likely could have reduced the pain there.

[ritaandscooter1 in reply to EPguy]

The Bes would definitely interact with the vaccine. I had a horrible reaction when I was on Peg and had the booster shot. The two prior vaccines I wasn't on Peg and had very mild reaction.....subtle headache is all. Hope all is well with you. Kerry

[EPguy in reply to ritaandscooter1]

My after effects were tolerable, just bad enough to know it worked. If IFN added to it, that was good in my case, WBCs getting called up more. I'll gladly take that over my MPN malaise. But I have seen here some had severe reactions to the vax so my result is not generalize-able of course.

The stronger reaction likely also relates to the higher vax dose in this round vs the 1st three at lower doses. Getting Pfizer would reduce odds of reactions but no assurance of that.

[Pennypen]

My specialist told me not to take Astra Zeneca so I didnt take any. I have had covid and have been ok. Just shows they jabs dont do as what they are supposed to do

[EPguy in reply to Pennypen]

The AZ shot, and the similar J&J shot, (adenovirus type) were found to have still low but higher risks of bad effects than the mRNA shots (Pfizer, Moderna) So neither of these two is normally offered by UK or USA anymore. So your specialist was up to date.

The early versions of Covid were not ok, we had a pre-vax near death experience and now long Covid to find that out. But even with Omicron as you can see here for California, there are still patients with Covid in ICU. UK Covid deaths are still seen on this page, and in fact are up a bit:

worldometers.info/coronavir...

The jabs are in fact doing what they are supposed to do, (prevent the worst outcomes) but not doing what we hoped they would do (prevent infection entirely). What they are doing is keeping us off the plot here, vaxed patients are much less likely to be on this curve or the one above for UK.

Omicron ICU