interferon resistant

[yippinurse]

I was on pegasys(max dose) for 3 years with hydrea and now on besremi since April with titration of hydrea. Since off hydrea my numbers have been creeping up. I think I'm one of those that are semi-resistant to interferons. Can you continue to use hydrea with besremi? Someone had posted the genetics that would show interferons will not work for you. Can someone send me that research?

[hunter5582]

Sorry to hear that the IFNs have not been as effective for you. My own situation is the exact opposite. The IFNs are much more effective and easier to tolerate than HU.

I believe the research you are looking for may be comparing the efficacy of IFNs with JAK2 vs CALR mutations. Here is one example.

pubmed.ncbi.nlm.nih.gov/304...

Hope you get things worked out.

[EPguy]

Here is another sample report on IFN vs mutations:

<<Furthermore, treatment-emergent DNMT3A mutations were significantly enriched in IFNα–treated patients not attaining CHR>>

ncbi.nlm.nih.gov/pmc/articl...

Do you have NGS (deep sequencing of many MPN related mutations)?

I've posted on this report before, it has a lot of good info.