MF and inflammation - Angela Fleischman

[Paul123456]

Interesting presentation, inflammation is a major contributor if not instigator of MF

a-guided-tour-of-inflammati...

[Mostew]

Thanks .she has a great approach.

[hunter5582]

Nice presentation. I certainly agree witht he core premise about the importance of managing inflammation. I do think inflammation is a risk factor for progression. It also has negative impact on quality of life. Controlling inflammation is a good thing!

[Paul123456 in reply to hunter5582]

My fibrosis is increasing and I’m knocking on the door of MF despite LDH c.100 and CRP under 0.3. I follow a textbook anti inflammatory lifestyle re diet and exercise, only vice is red wine.

It does appear that there is a sub group who progress to MF despite very low inflammatory markers

[hunter5582 in reply to Paul123456]

All we can do is what we can do. The anti-inflammatory lifestyle also makes us feel better and controls symptoms. Do note that red wine has resveratrol and anti-oxidants. Those are good for you.

[BrookTownsend375 in reply to hunter5582]

.Hunter, please tell us exactly the name of the red wine you drink, I am assuming just one 7 oz. glass a day--BrookeTownsend

[Aneliv9 in reply to Paul123456]

Your LDH is 100 so on the lower limit of range?? CRP is also in the normal range??? Could you tell us more about your diagnosis? I read that you had ET and then PV/MPN-U. What characteristics has this PV/MPN-U??

[Paul123456 in reply to Aneliv9]

I think I have an aggressive version of PV, dx with fibrosis, two mutations, 80% JAK2.However had a great response to Pegasys but partly stymied by my TET2 mutation.

[beetle]

Thank you for posting this. It is so reassuring to know that research is carrying on to give us all hope. Although some of these presentations are so full of scientific terminology that I get bogged down in and sometimes give up I can always get the gist of what it is about. Research looking at things other than the Jak stat pathways I find most exciting of all.

[EPguy]

This quote stands out:

<< If you were to somehow get rid of the mutation in a patient with MF, you would still be left with the problem.>> This is distinct from "reducing" the mutation, implying even with zero mutation MF persists. I'd like to know where that data came from.

Implication is inflammation may be the path out. Some of the inflammatory cytokines (TNF-α, IL-1, and IL-6) noted are alleged to be regulated by certain supplements. She is studying one of them, NAC.

[Emmyroos]

This is an excellent presentation. Thank you for sharing. It's a bit daunting to think that even if we can reduce the JAK2 mutation, the disease may have other unknown pathways. But I guess most diseases are multi-variable.

I had the pleasure of taking part in Dr. Fleishman's NUTRIENT clinical trial. I was given a specific diet and measured inflammatory cytokines before and after the diet. I wasn't offered my own personal data from the study but it was interesting to partake in regardless.