inflammation and ET HU

[130396]

How do we treat inflammation ! ?

[hunter5582]

The overproduction of inflammatory cytokines is a core aspect of MPNs symptoms and management. There is unlikely to be one size fits all interventions.

Some have had success with an anti-inflammatory diet, most often a Mediterranean Diet. There is some research supporting he use of N-Acetylcysteine (NAC).

I consult with an Integrative Medicine doctor for this specific issue. She recommended a combination of curcumin, L-Glutathione (alternative to NAC), and a Proresolving Mediator (fish oil derivative). The curcumin in pariticaly makes a significant difference in the osteoarthritis symptoms I experience.

Suggest consulting with a MPN Specialist rather than a regular hematologist on the issue of managing inflammation. If you wish to consider complementary health interventions, then consulting with an Integrative or Functional medicine doctor can be very helpful.

Wishing you success moving forward.

[130396 in reply to hunter5582]

Thank you hunter5582 .

Professor Harrison knows I have inflammation but doesn’t relate it to my ET.

At her suggestion I was referred to a Rheumatologist. I can’t take cucurmin as I’m on warfarin . Likewise I can’t take Omega 3 or anything which will thin the blood due to the warfarin..

Are you in UK? Where on earth would u find an intergrated Doctor who understands ET?

I’ve also got lupus anticoagulant and multiple clots in lungs

[hunter5582 in reply to 130396]

I am in the USA. I was fortunate to find a very knowledgeable Integrative/Functional Medicine doctor locally. there is a list of Functional Medicine doctors that includes the UK. ifm.org/find-a-practitioner/

You may find an Integrative Oncology unit attached to some hospitals. There are some Integrative Medicine practices in the UK. ncim.org.uk/ You would have to look for something close to you.

My MPN care team is in agreement that inflammation is a core issue with MPNs. They do not, however, offer any solutions to systemic inflammation. That is the realm of my Integrative medicine doctor. She is also the one who identified that Milk thistle extract could reduce the impact of Besremi in my liver (returned LFTs to normal).

Given that you have LA in addition to ET, your situation is quite complex. Anything that causes inflammation can cause reactive thrombocytosis. The deregulated JAK-STAT pathway increases the production of inflammatory cytokines, complicating things further. Our bodies are integrated systems where there are complex processes and interactions occurring. There can be significant benefit to consulting with a doctors whose discipline looks at the body in this way. It can be particularly helpful to find an Integrative (or Functional) Medicine doctor with a strong background in oncology.

Wishing you all the best.