There are a couple of things you can do to improve your odds of reducing thrombocytosis. Reducing systemic inflammation has the benefit of improving quality of life/better functionality and creating an environment in your body that does not promote the overproduction of platelets. There are several strategies you can use, one of which is an anti-inflammatory diet(e.g. Mediterranean Diet). Some us have found supplements that can help reduce inflammation. These include curcumin, N-Acetylcysteine, L-Glutathione. If you choose to use a supplement, your care team needs to know. I consult with an Integrative/Functional Medicine Specialist about the use of these complementary health approaches.
Staying well hydrated is also a very good idea. It will not reduce the thrombocytosis but will reduce risk. And you will feel better overall. This is particularly important when using hydroxycarbamide as It helps reduce/manage the toxicity.
I went on to a Mediterranean diet, included garlic, ginger and other anti inflammatories in my diet and took curcumin. For the best part of a year it seemed as though my platelets were very slowly reducing and I was able to reduce the hydroxy by 2 tablets a week. Then, for some reason the platelets went up again and my hydroxy doseage had to follow suit. I haven't been able to get it down again, but I keep trying! As Hunter says discuss any supplements with your haem.
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