There have been discussions here of travel with INF.
I recently used the ice pack that comes with Besremi in a lunch cooler for my Dr office visit. After that I placed it in my office fridge for the day. I realized a possible hazard to that: if the ice pack were below freezing temp, and the lunch box is in the fridge, the INF could get too cold or even freeze. Worried about that I tested the box next day with plain water instead of medicine. The water stayed liquid, all is good. But it did feel very near freezing.
I think the ice pack is plain water, but even that can go below 0 deg C for a while if it is stored at normal freezer temps. Some ice packs might also freeze at less than 0 deg, if they were salt water for example. I'm not sure such packs exist however.
In summary, to be safe I plan to remove the ice pack from the box after ~15-30 minutes once the travel box is in the fridge, and replace the ice pack when ready to take it back out. I'll put the ice pack by itself in the freezer in the mean time.
So far this is just a theoretical concern but welcome any comments.