Ropeginterferon alfa-2b versus phlebotomy in low-risk patients with polycythaemia vera (Low-PV study)

[Manouche]

There is no evidence that phlebotomy alone is sufficient to steadily maintain haematocrit on target level in low-risk patients with polycythaemia vera. This study aimed to compare the efficacy and safety of ropeginterferon alfa-2b on top of the standard phlebotomy regimen with phlebotomy alone.

thelancet.com/journals/lanh...

[Bigcheat]

Thanks Manouche!

I wonder, has anyone on the forum received Ropeg therapy yet? If so, what were the results?

Cheers,

Bigcheat

[JohnSC in reply to Bigcheat]

Hi,

I am in my 2nd month of Besremi, also known as Ropeginterferon. It is early days but so far the experience is very positive.

[Bigcheat in reply to JohnSC]

Thanks JohnSC,

Keep us posted about your progress, will you. I have understood Besremi should have fewer side effects than Pegasys. Hope it works for you!

Cheers,

Bigcheat

[JT_Marlin]

I believe an application was submitted in the US to the FDA in June 2020 - should be a result early this year.

[Bobadog]

Many thanks Manouche for this post about the study in the Lancet.May I ask the effects on moderate exercise (daily walk /swimming etc )for patients with PV taking Pegays Interferon? Are there many patients on this site taking Peg ,who continue their sport ,when fatigue allows?I am now poorly controlled with monthly venesections,(450 mls)and suffer with increasing fatigue,most probably due to iron deficiency,

Thankyou,

Alex

[Manouche in reply to Bobadog]

Hi Bobadog,

I’m back to daily swimming at a local outdoor swimming pool. At the moment I find it hard to swim my usual 1.5km in less than 30’ but I not sure whether I should blame Pegasys or the lack of training.

[Bobadog]

Hi Manouche,Good to hear that you are still enjoying your swimming ,

Many thanks,

Alex