Headache Remedy

[runnerbird71]

Does anyone know if it’s ok to take any other headache medicine alongside 81mg of aspirin and jakafi 20 mg twice daily?

I’m newly diagnosed with myelofibrosis and just got insurance so I will be getting a specialist next week. My hemotologist is not good with giving me much info. I have to research everything myself.

I have been in the meds for 8 weeks and while they help greatly with bone pain I have begun to get terrible headaches and a pain in my lower right back. I also urinate often so I am thinking it may be a uti. Gonna get some lab work soon.

Thank you and happy new year everyone🌈

[Cja1956]

Happy New Year to you, as well. I’m post ET MF, having been diagnosed with ET in 2008, and MF a year and a half ago. Your symptoms do concern me, especially the lower back pain. I have had frequent UTIs over the years and I’ve ended up in the emergency room several times because I ignored the symptoms. About 2 years ago, the emergency room doctor said if I had waited any longer my kidneys would have gone into sepsis. Also, I have taken ibuprofen on occasion for various things like back pain or headaches. It does help, but I don’t know if it’s the right thing to do. You really do need to consult a doctor. I am in the US, and I am on hydroxyurea, a new drug called Inrebic, and baby aspirin. Good luck! I hope you can find an MPN specialist to treat your myelofibrosis but in the meantime, you should have your back pain checked out. If you have an infection, you need to start on some antibiotics.

[runnerbird71 in reply to Cja1956]

Hmmm. What were your symptoms? I don’t honk ibuprofen is good mixed with aspirin. Thank you for responding

[Cja1956 in reply to runnerbird71]

I’m sending you a private message

[Tico in reply to Cja1956]

I was advised never to take Ibrufrofen when I was taking Aspirin. I now take Clopidogrel and asked whether the same still applied, I was told yes because of the blood thining properties already in them. Paracetamol is reccomended. Best wishes, Tina.🤗

[Wyebird]

Hi, I’m on anagrelide and hydroxi. I take headache tablets. The difference is I have ET. Good luck do mention the headaches to your heamo. X

[hunter5582]

You are wise to think about the drug interactions between low-dose aspirin and other analgesics. The broad answer to your question is that acetaminophen is the analgesic that has the lowest drug interaction profile with aspirin. Ibuprofen and naproxen both potentiate the blood thinning properties of aspirin. Here is the info from ePocrates interaction check.

Avoid/Use Alternative naproxen + aspirin

avoid aspirin >325 mg/day; otherwise, monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (incl. life-threatening), renal impairment; naproxen may inhibit cardioprotective effect of low-dose aspirin (additive effects; antagonistic effects)

Avoid/Use Alternative

ibuprofen + aspirin

avoid aspirin >325 mg/day; otherwise, monitor bleeding s/sx, renal fxn; give ibuprofen dose >400 mg 8h before or at least 2-4h after low-dose aspirin ER: combo may incr. risk of GI ulceration, perforation, bleeding (incl. life-threatening), renal impairment, other adverse effects; ibuprofen may inhibit cardioprotective effect of low-dose aspirin (additive effects; possible competition for platelet binding sites)

Monitor/Modify Tx

acetaminophen + aspirin

monitor renal fxn, especially w/ long-term concomitant tx: combo may incr. risk of nephrotoxicity (additive effects)

All of my docs have always been very clear with me about using acetaminophen rather than the other analgesics when pain relief is needed. I have used it post-surgically on multiple occasions without any trouble.

Please do review this with a medical professional to verify this is good advise in your specific case. Like all medications, acetaminophen has its own risk/benefit profile that needs to be considered.

All the best to you.

[runnerbird71]

Thank you

[AndyT]

I try to use paracetamol but have been told that occasional use of ibuprofen is also ok if needed

[Pte82]

runnerbird71, your headache may respond to magnesium, which also keeps platelets from sticking together and needed to activate thiamine and vitamin D. Probiotics are important for urinary health and are often overlooked. NAC can be used with Jakafi and offers serveral benefits one being able to detoxify the liver from acetaminophen. Always consult with your doctor before using any supplement.

hindawi.com/journals/crim/2...

verywellhealth.com/vitamin-....

krispin.com/magnes.html

[runnerbird71 in reply to Pte82]

Thank you