Worth reading if considering Pegasys

[Paul123456]

Dr Silver is the Interferon guru, based of his long experience using Interferon as a first line treatment choice. Also he recommends INF/Pegasys at an early stage when patients still low risk. Most Hems tend to use HU as front line drug and won’t medicate for low risk patients

onclive.com/publications/mi...

[CommonDaisy]

Thanks Paul. Very interesting read and reassuring for those of us on interferon 😊

[katiewalsh]

Thanks Paul. Have you seen studies about which drug is best for ET? My MPN isn’t really classified. Some say ET, some say post ET pre MF, etc. Lately I’ve experienced a huge increase in frequency & severity of fatigue. But my CBC hasn’t changed. I’d appreciate knowing of any studies that might be applicable. Thanks, Katie

[Paul123456 in reply to katiewalsh]

Katie

I’m PV/MPN-U (Unclassified) JAK2. My first BMB was ET. My understanding is that Interferons work on ET, PV and early MF. I think the budding excitement about Pegasys/INF is that it might reduce/slow the risk of progression. However this is ongoing, subject to trial results.

I’m also TET2 mutation which, based on limited research, is meant to inhibit Pegasys efficacy.

I’ve been to Pegasys for 12 months. Started 45 mcg weekly and increased to 110 mcg currently. No significant side effects at all and reduced my pruitus.

My AB was 75%, now 50%. Platlets 600, now 150, RBC 6.2, now 5.9 and WBC 12, now 2.5.

Going to have to reduce dosage to get WBC back up.

As you can imagine I’m a Pegasys fan but everyone reacts differently

Best Paul

[katiewalsh in reply to Paul123456]

Thanks Paul. Good luck to you. Katie

[Bluetop]

Thanks Paul. My haem still recommended I stay with hydroxy for the moment -while it is working well, but it is very reassuring to hear the growing confidence in interferon drugs.