Total Body Irradiation Dose Escalation Decreases... - MPN Voice

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Total Body Irradiation Dose Escalation Decreases Risk Of Progression And Graft Rejection

Paul123456
Paul123456

Promising trial results reducing risk of GVHD and progression.

“The primary endpoint was day 200 hematopoietic cell transplant failure, with the objective of reducing the incidence to <20%. Primary endpoint was reached on Arm A at dose Level-1 (300 cGy total body irradiation) with a cumulative incidence of day 200 hematopoietic cell transplant failure of 11%, and on Arm B at dose Level-3 (450 cGy) with a cumulative incidence of day 200 hematopoietic cell transplant failure of 9%. Increasing the total body irradiation dose leads to a higher success rate with nonmyeloablative conditioning by reducing relapse and rejection.”

haematologica.org/content/e...

1 Reply
oldestnewest

Some good news! Thanks for posting.

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