MPN Voice
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Video re progression

Interferon appears only drug that might slow progression but some people can have severe side effects. Ropeginterferon, which hopefully will be available next year, is better tolerated and (I thought) more efficacious.

They say the focus is on finding better drugs for MF rather than slowing progression but don’t mention RG7388 which does appear to target a serious mutation (MDM2) that could speed up progression (by stopping p53 gene from working properly). I guess the respondent is referring to finding the as yet unknown prime driver. Hence at the moment drugs (such as RG7388) are targeting secondary mutations that speed progression. Still very useful but not yet universal one shot ‘cure’

2 Replies

Great link Paul thanks for sharing, your posts always show that there is new hope out there for us.


Thanks Paul. It is very good to have a clear explanation of this new interferon. I picked up a copy of MPN magazine at my last appointment and read about it. I asked consultant about its benefits. I can't remember her exact explanation although I could draw it! Anyway she said it may be more effective but trials not complete. Your explanation has given me more food for thought.



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