Hello I was diagnosed with ET + jak 2 18 months ago, I'm 67 and take hydroxy and an aspirin daily. I'm on holiday in the Canaries at the moment but wanted to follow on from a post and replies I've just read. I feel blessed to have had so few side effects from the drug and generally speaking lead a fairly normal life. Reading the recent post though reassured me as I realised reading others experience that what I feel sometimes is quite normal. I'm learning as time goes on that I'm not as I used to be. For instance we had a 12 hour journey here which took me so long to get over, I felt terribly tired. I kept myself hydrated but I was shattered for days. I also had a massage on my 4 day which left me feeling worse, the therapist explained this can happen sometimes as it would have shifted the hydroxy around my body making me feel unwell, I've never had that happen before. Some days the heat and any form of exertion gets to me. These are all new experiences. I try to keep going and up with others, eating and drinking a small amount of alcohol but I don't find it easy and socialising can be more of a bit deal. As others have commented it's difficult to know what is age related or due to the complaint. I'm determined to keep as active as possible and keep doing what I want but I find it hard to understand the way my energy fluctuates, sometimes from one day to another when I haven't necessarily done anything different. It's so helpful to hear others go through the same. I was heartened to see someone had posted they are in Oz, that's a journey I'm not sure how I would cope with.