I've been on HU for 5 weeks, 2 weeks on 500 mg a day then 3 weeks on 500 mg one day and 1000 mg the next. When I started my platelets were about 1060, after 2 weeks on HU they were at 887 and after a further 3 weeks on the higher dose they are now at 805. I've seen the hem today and they have put the dosage up to 1000 mg each day. I go back on Christmas Eve for another check. The hem said my platelets should have come down quicker and it may not be suitable for me. I wondered what other alternatives there were, or whether I should persist with the HU? I had headaches and lots of acid in my stomach at first but that has faded alot now. I've been to the dentist today and my mouth is clear. I'd welcome any input.