My ana is negative, but dsdna is positive, what does this mean?

[dancer44wolves]

Dsdna lupus

[Tanitani]

Probably your ANA test used methodology thats not sensitive enough.I found the answer on the internet: ANA test is a screening test and is performed by different methods in different laboratories. Some methods are more sensitive (like ANA using HEP2 cells by IFA "the gold standard", but higher false positive rate) and others are less sensitive (but lower false positive rate): ELISA with only a few selected antigens or Multiplex Bead immunoassay testing only 12 different antigens which are either recombinant, native bovine-derived or synthetic (such as dsDNA).

[dancer44wolves in reply to Tanitani]

Thank you, that makes sense!

[Ingrid1234]

Symptoms, tests and diagnosis for lupus:

lupusuk.org.uk/wp-content/u...

Some basic information.

[dancer44wolves in reply to Ingrid1234]

Thank you!

[Chanpreet_Walia LUPUS UK]

Hi dancer44wolves,

An ANA test only confirms whether or not a person has an autoimmune disorder, it does not confirm if a person has lupus. According to The Lupus Encyclopedia, an ANA test result can be ‘negative’ in around 5-10% of people with lupus.

dsDNA antibodies are very specific in people with lupus, as they are not typically seen in any other condition or in healthy population, however only approximately 60% of people with SLE will test ‘positive’. Therefore if someone is positive for these antibodies, it often means they have lupus. For more information, you can read our blog article on ‘getting a diagnosis of lupus’ here: lupusuk.org.uk/getting-diag....

Have you been referred to a rheumatologist? Before attending your appointment you may like to read our blog article about getting the most from medical appointments here: lupusuk.org.uk/getting-the-...

Best wishes,

Chanpreet