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About to start Etanercept (Enbrel) injections - any helpful tips?

I am about to start Etanercept injections (also taking MTX hydroxychloroquine, predisolone 10mg, tramadol etc) for RA/lupus overlap. I was wondering if anyone could give me their stories. What side effects, did it work, how long did it take to work etc. All comments gratefully received. Bit nervous about starting it, but sooo desperate to feel just a little better.

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I've been taking enbrel for 22 weeks. It worked a little for me but not enough ( I'm taking it for RA). The main problem people seem to have is a site reaction. I made sure I alternated the side I injected. At first I did get a redness but used antihistamine cream, and for a while the antihistamine tabs you could buy over the counter. They recommend that you take it out of the fridge about 30 mins before use. Sometimes the final bit of the injection hurts and may draw blood a little. Nothing to worry about, I just held the antiseptic wipe over it.

I hope things go well for you.



I've been on the weekly 50 mg injections for about 4 years now. It's better than steroids, doesn't bother your tummy, works a bit slower than steroids. I agree with Cathie, take it out of fridge at least 30 min. before injecting. And you may need some Benedryl cream for the injection site. I inject mine under all the loose skin on my lower belly, but you can use your thighs.

One of the easiest, and as of today one of the least in bad side effects that I've been on. And on over 35 years of fighting these (RA/Lupus) one of the fastest working. And Baby, I think I've been on them all.

Best of luck to you,

Bama Housewife


Sorry I'm just interested in what these injections are ? Are they for lupus ?:)


I give myself a shot under the skin every week.I believe it is for RA, however it decreases inflamation both in my joints and soft tissues :)


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