Lung Matrix Trial

[ParchWoody]

I’m being referred to Christie from Clatterbridge to take part in SMP2/Lung Matrix Trial? Has anyone taken part in this trial? How was it? Thanks for your time.

[Fifi24]

Hi, sorry you have this disease, I hope you kick it right out...I know of some that went on this lung matrix trial in Birmingham... but it had only just started its trials, so worked at the beginning, but in their case, their health was not good, it did not work for them... remember not everyone takes the same trail, of course their treatment was 3 years ago, these trials were in their early stages then... my husband was on the list to start, but sadly he did not stabilise in health for him to start it...

So this trial has been around for more then 3 years that I know of... it must have come along way...

I really hope and pray it works for you... as they use new treatments potentially can have an amazing result.

Its key to let them know about any side effects as early as possible, getting the side effects treated early too.

[ParchWoody in reply to Fifi24]

Thank you for your encouragement and prayers.

[Wiseowl1]

Hi...I'm just waiting for my biopsy results to be done for the matrix trial at qe Birmingham...Will keep intouch and update you as an when..

Good luck woody

[ParchWoody in reply to Wiseowl1]

Thanks and Good Luck to you too.

[Hidden]

Hi I was diagnosed with NSCLC (never smoked) in Feb 2017 After first round of chemo I was on Pemexetred maintenance for 10 months but when that stopped working I went on SMP2 trial. There are several different arms to the trial and a drug will be chosen for you depending on your mutation. The trial was run from Birmingham but I had treatment at Southampton. I had a great response at first with a lot of shrinkage and I started to feel really well. Unfortunately after 5 months it stopped working As I had 2 mutations I was able to go on another arm of the trial The second drug kept things stable but had more side effects Ive just been taken off this drug and am waiting to go on Immunotherapy.

I would definitely recommend you go on a trial. I received amazing care at Southampton and although no longer receiving trial treatment my condition is better than before I started it. I hope it works for you

[ParchWoody in reply to Hidden]

Thank you hope all goes with the immunotherapy.

[Hidden in reply to ParchWoody]

Thanks Let me know how you get on

[RoyCastleHelpline Partner Ask the Nurse Roy Castle]

Dear ParchWoody

As you may know the Lung Matrix Trial is looking at a number of different medications (up to 8) to treat non small cell lung cancer. It's aim is to match the medication that will work with the genetic changes in the cancer cells. Therefore depending on the gene changes in your cancer cells, this will direct what treatment group you will be allocated to.

However, it is an open label trial so you will know what treatment group you will be in which may help if you are looking for shared experiences on the forum.

This link will take you to the information on the trial:

cancerresearchuk.org/about-...

Taking part in a clinical trial provides excellent care and attention to detail (on top of the care you already receive at clinic) of how you feel and any changes in your health are addressed promptly. When you attend the Christie the research team will explain everything to you fully about the trial and what is involved for you. It is voluntary and you can withdraw at any time.

If you wish to discuss anything you can call us on our free nurse led helpline number on 0800 358 7200

All the very best

The Roy Castle Support Team

[Hidden]

Like you I have just been referred to the same trial in Birmingham...I was diagnosed with Stage IV adenocarcinoma EGFR+ in Feb 2019. Still trying to get my head around everything as cancer was found 'incidentally' and I am a non-smoker and quite healthy. Does feel like I have stepped into a parallel universe and getting used to all the terminology, but, from what I understand they will test across all of our gene characteristics, not just the 5 currently available through the NHS, then if accepted and a match, any new and appropriate therapies will be offered to us.