Hi, I've just started crizitonib as targeted therapy. It's only been two weeks but I can feel the fluid building up again. I had a drain two weeks ago and then three weeks before that. I presume it's fluid because my fatigue is terrible and I'm breathless. The consultant has mentioned vats pleurodesis, any advice? It sounds scary stuff, is it permanent? Is it done under general or local? I wish they would just remove the lung. I was hoping crizitonib would clear up the fluid situation?