I've started my fifth week on Doxycycline, and didn't think it was doing a lot, as I was getting periods of pain each day. I've got erysipelas affecting both lower legs.
I read some guidance that advised 200mg once per day, and I'd been taking 100mg twice per day. I discussed this with my GP and pharmacist and tried 200mcg in one dose for the first time yesterday.
Taking a day's dose in one go caused a bit of nausea. I hope I won't suffer intracranial hypertension. On the first day, my legs swelled and had increased surface blood flow (inflammation?) up to the top of my thighs. The thigh swelling and pinkness had gone today, and there's been very little discomfort.
It looks like this surge of the antibiotic was needed, and I can finally get rid of the infection. It's been a scary ride!