Can you have Sjogrens without an APS diagnosis?

[Wittycjt]

I thought you had to have APS in order to have Sjögrens but i see another post as this not the case. Please educate me

[baba]

sjogrens.org/home/about-sjo...

[Wittycjt in reply to baba]

Thank you

[Jmiller623]

I think you can have Sjogrens without APS. I’m unsure of the percentage of overlap. Sjogrens is no more than lymphocytic infiltrate of endocrine organs - salivary, pancreas, thyroid (likened to Reiters), lacrimal. This can be diagnosed with biopsies without antibodies. I think suspicion for primary APS should be raised in those with positive anti-Ro, negative ANA while suspicion for SLE with APS should be considered in those with anti-La. This is how I understand APS, SLE, SS overlap.

Publication for reference:

pdfs.semanticscholar.org/6a...

[Wittycjt in reply to Jmiller623]

Thank you

[bookish in reply to Jmiller623]

According to the 'Sjogren's Syndrome Survival Guide' nearly 5 % of primary Sjogren's patients and 13 % of secondary have APS. They also draw attention to the neurological aspects of Sjogren's - according to John Hopkins, more than 50% of patients with neurological manifestations of Sjögren’s syndrome may not have autoantibodies hopkinssjogrens.org/disease...

[Wittycjt in reply to bookish]

Ty

[HollyHeski Administrator]

Sjogrens is an autoimmune disease of its it's own, you can have primary APS or primary SS, without the other. It is also common to have both, with one being the primary and the other being secondary. You dont have to have APS to have SS.

[Wittycjt in reply to HollyHeski]

Ty