I am constantly researching, trying to find out as much as I can about the body and this crazy illness. I came across this very interesting article and thought I would share. It mentions viruses as a precipitating factor to autoimmune hyper coagulation. It doesn't specifically mention Hughes but does mention an "anti phospholipid syndrome". I have consistently tested positive for one of the three viruses mentioned (cytomegalovirus) and have ever since 2008.
Not sure if anyone else has history of viral infections but could be a piece of the puzzle.