Hi all I haven't posted on her for a while but things are getting gradually worse for me. All my joints hurt, ankles, knees, elbows and wrists. Wonder if I should be on plaquenil as lots of people on here seem to be. Or also wondering if it could be that my INR is too high. My range is 3-4 but is still not settled and is going up and down like a yo-yo and has been like this for months. Could this also cause it do you think? It went up to 4.6 a couple of weeks ago then dropped to 4.2 then to 3.5. I still also get cluster migraines no matter what my INR is. Feel like I'm falling apart. I have had APS for 25 years but only really in last 2 years I have been having all these problems. Any ideas please? Not due to see Prof Hunt again until October.