Bladder inflammation with estrogen cream

[Pinkruby701]

Has anyone ever had irritation after using vaginal estrogen cream??? I had a total hysterectomy and have no ovaries. Just found out my estrogen level is a 40. It was a 70 a few months ago and now it's plummeted. I use the estrogen patch but have also been told to use the cream. It's a bioidentical cream with no allergens or irritants. It does NOT irritate my vagina. But whenever I use I wake up with bladder pain the next day. Could it be because the tissue is dries and irritated and it will just take time?? Or is it a histamine reaction?? I don't know.